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Abstract #1219

Quantitative 129Xe MRI detects early impairment of gas-exchange in a rat model of pulmonary arterial hypertension

Rohan S Virgincar1, John C Nouls2, Simone Degan2, Xinyu Xiong3, Ziyi Wang1, Yi Qi2, Sudarshan Rajagopal3, and Bastiaan Driehuys1,2

1Biomedical Engineering, Duke University, Durham, NC, United States, 2Radiology, Duke University Medical Center, Durham, NC, United States, 3Department of Medicine, Duke University Medical Center, Durham, NC, United States

Hyperpolarized 129Xe MRI is capable of regional mapping of gas-exchange and has found application in a wide range of lung disorders. Here, we apply 129Xe gas exchange MRI and dynamic spectroscopy at 7 Tesla to study a rat model of pulmonary arterial hypertension. 129Xe spectroscopy and gas-exchange imaging showed reduced uptake by RBCs early in the progression of the disease, and at later time points was accompanied with increased uptake by barrier tissues, structural abnormalities, edema, and ventilation defects. Imaging results were compared to H&E histology, which showed evidence of vascular remodeling.

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