We propose a method to reconstruct 1-mm3 isotropic T2 maps based on multiple 2D multi-echo spin-echo (MESE) acquisitions. To compensate for the prolonged scan time due to multiple acquisitions, data were highly (10-fold) undersampled. The data was reconstructed by combining a classical super-resolution approach with an iterative model-based reconstruction. The method was tested on a phantom and four healthy volunteers. T2 values were compared against fully sampled MESE data. The proposed technique allows the assessment of T2 values in brain structures at high isotropic resolution.