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Abstract #1263

Creatine CEST at 3T following in magnet exercise shows differences in heart failure patients with preserved ejection fraction compared to healthy and hypertensive controls

Neil Wilson1, Payman Zamani2, Elizabeth Proto2, Kevin D'Aquilla1, Dushyant Kumar1, Deepa Thakuri1, Hari Hariharan1, Shana McCormack3, Julio Chirinos2, and Ravinder Reddy1

1CMROI, University of Pennsylvania, Philadelphia, PA, United States, 2Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, United States, 3Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States

Exercise intolerance is a hallmark of heart failure. Here, we have shown for the first time that parameters derived from ROI-based analysis of creatine-weighted CEST signals following exercise can be used to distinguish HFpEF patients from HTN and healthy controls. Identifying these group differences is uniquely possible because CrCEST can measure muscle specific metabolism with high spatial resolution and sensitivity.

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