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Abstract #1275

Extended phase graph model based tissue-water T2 estimation from CPMG image data in fat-infiltrated skeletal muscle: application in amyotrophic lateral sclerosis and Kennedy’s disease

Nick Zafeiropoulos1, Uros Klickovic1, Luca Zampedri1, Stephen J Wastling1, Christopher J Sinclair1, Jasper M Morrow1, Robert X Janiczek2, Enrico De Vita3, Tarek A Yousry1, Michael G Hanna1, Linda Greensmith1, Pietro Fratta1, and John S Thornton1

1UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 2Glaxo Smith Kline, London, United Kingdom, 3Department of Biomedical Engineering, King’s College London, London, United Kingdom

An MRI CPMG extended phase graph signal model was used to determine muscle-water T2 (T2m) in fat-infiltrated skeletal muscle, using a fixed two-component approximation to the fat signal. Stable estimates of T2m and apparent fat fraction (ffa) in the thigh muscles of amyotrophic lateral sclerosis and Kennedy’s disease patients and healthy controls were obtained. T2m were elevated in both patient groups, as was ffa with a distribution consistent with that obtained by 3-point Dixon MRI.

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