Application of DTI to map the complex collagen fibril structures in preclinical studies of the knee joint is still challenging, due to the limited spatial resolution previously used, relative low FA values, and relatively low signal-to-noise (SNR). We imaged the rat knees in a preclinical 9.4 T system with powerful gradients (2000 mT/m) to minimize TE. A modified 3D diffusion-weighted spin-echo pulse sequence was used to achieve isotropic spatial resolution at microscopic scale.
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