The study aim was to identify the highest value sequences for assessment of multiple myeloma by whole body MRI (WBMRI) to optimize scan acquisition and read times. Individual sequences (Dixon -/+ contrast, and diffusion imaging) were assessed in a prospective cohort of 29 patients with newly diagnosed multiple myeloma. Scan sensitivity, positive predictive value and reader confidence in detecting myeloma lesions and lesion conspicuity were assessed. Post-contrast water only Dixon and diffusion weighted images performed best. The results suggest that scan acquisition and read time can be reduced by focussing on WO contrast enhanced and diffusion images.