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Abstract #1379

Exploratory evaluation of magnetic resonance fingerprinting confirms increased T1 and T2 in metastatic breast and prostate cancer lesions compared with normal marrow and volunteer values

Matthew R Orton1, Mihaela Rata1,2, Nina Tunariu1,2, Julie Hughes2, Erica Scurr2, James A d'Arcy1, Martin O Leach1, Wei-Ching Lo3, Mark Griswold3,4, Yun Jiang3, Vikas Gulani3,4, and Dow-Mu Koh1,2

1CRUK Cancer Imaging Centre, Division of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom, 2Department of Radiology, Royal Marsden NHS Foundation Trust, London, United Kingdom, 3Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 4Department of Radiology, Case Western Reserve University, Cleveland, OH, United States

Magnetic resonance fingerprinting (MRF) is a rapid imaging technique that allows generation of multiple, co-registered quantitative maps from a single sequence. This technique has been evaluated in the brain, abdomen, prostate, breast and heart, but has not been applied to metastatic disease in the skeleton. This abstract documents T1 and T2 values obtained with MRF in metastatic bone disease, muscle, fat and bone marrow, compares them with values obtained in volunteers using gold-standard imaging and MRF and demonstrates increased T1 and T2 in lesions compared with normal marrow and values in volunteers.

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