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Abstract #1425

Quantitative MRI to assess disease activity change in children with juvenile idiopathic arthritis

Joshua Luke Bennett1, Amanda Wood1, Nicola Smith2, Ravi Mistry3, Karen Allen1, Sharmila Jandial1, John Mark Tuckett4, Claire Gowdy5, Helen E Foster1,2, Flora McErlane1,2, and Kieren Grant Hollingsworth2

1Paediatric Rheumatology, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 3Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 4Radiology, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 5Paediatric Radiology, British Columbia Children's Hospital, Vancouver, BC, Canada

Assessment of disease activity in children with juvenile idiopathic arthritis (JIA) is central to avoiding permanent joint damage. Affected joints are characterised by synovial proliferation resulting in synovial effusion and hypertrophy. Long-standing poorly controlled synovitis is associated with a high frequency of joint damage. 11 children with JIA were examined with quantitative MRI to measure synovial volume and rate of contrast uptake before and 12 weeks after routine intra-articular corticosteroid injection. All children showed marked reductions in synovial volumes, and in rates of uptake of gadolinium. These reductions were more consistent than changes in clinical assessments.

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