A 16-channel array coil has been developed in our laboratory for anesthetized monkey brain imaging at 3T, with a specialized design to accommodate multi-modal devices. Its performance has been evaluated on an anesthetized macaque. Compared to the commercially-available pediatric coil, the 16-channel monkey head coil showed improved receive sensitivity and superior acceleration performance. Further, the presented coil can accommodate multi-modal devices, allowing simultaneous optical imaging, neural recording, and stimulation, during high-field MRI studies. It is hoped that the proposed array coil could benefit a broad scope of research in frontier neuroscience.