MRI of the prostate has become a crucial component of prostate cancer diagnosis. Most clinical sites use 2D FSE for T2 imaging. However, drawbacks exist and some institutions have moved to 3D using FSE-VFL. While groups have presented clinical results using FSE-VFL, none have published detailed investigations of different flip angle trajectories and parameter choices for maximizing lesion contrast in prostate cancer imaging. Flip angle trajectories were simulated for 3D FSE-VFL using T1 and T2 appropriate for prostate and then tested in a phantom. Overall, signal simulations proved useful for analyzing different parameters and flip angle trajectories for T2-weighted sequences.