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Abstract #1647

MRI-based R2* Mapping in Patients with Suspected or Known Iron Overload

An Lesage1, Philippe Paquin1, Jack W Luo2, Milena Cerny1,3, Anne Shu-Lei Chin1, Damien Olivié1, Guillaume Gilbert1,4, Denis Soulières5, and An Tang1,3

1Department of Radiology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, 2McGill University, Montréal, SK, Canada, 3Centre de recherche du Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, 4MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, 5Department of Hematology-oncology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada

The purpose of this study is to analyze the cross-sectional relationships of MRI-based R2* relaxometry values in organs across patients with various types of iron overload. Further analyses were conducted to analyze R2* values in organs according to the treatment regimen of patients (transfusion, phlebotomy, and chelation therapy). This retrospective, cross-sectional study includes 82 adult patients with known or suspected iron overload due to primary and secondary hemochromatosis. Results revealed differences between degree of iron overload in organs according to the underlying pathology and treatment regimens.

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