Intravoxel incoherent motion, a bi-exponential model of diffusion-weighted imaging with multiple b values, can represent pure molecular diffusion and perfusion, and be used in characterizing focal hepatic lesions. Recently, stretched exponential model has been used in glioblastoma and prostate cancer. In this study, we evaluated the feasibility of stretched exponential model for differentiating benign and malignant hepatic lesions. Our results showed that DDC value from a stretched exponential model was the highest diagnostic potential, so it could be a quantitative imaging biomarker for differentiating benign and malignant hepatic lesions.
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