To evaluate the diagnostic performance of DWI radiomic signatures for the assessment of breast cancer receptor status and molecular subtypes. Ninety-one patients with breast cancer were included. Lesions were manually segmented on high b-value DWI and propagated to ADC maps. To compare different segmentation approaches a subgroup was directly segmented on the ADC map. Results demonstrate that DWI radiomic signatures enable the assessment of breast cancer receptor status and molecular subtypes with high accuracy. Higher accuracies are achieved when segmentations are performed directly on ADC maps that cancel out T2 shine-through indicating as the preferred approach for radiomic analysis.