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Abstract #1732

Three-dimensional MR Elastography (MRE) can replace 2D MRE in staging liver fibrosis: Noninferiority test of the area under the ROC curve and comparison of image quality.

Hao Yang1, Hezhi Lu2, Yong Liu3, Sichi Kuang1, Bingjun He1, Kevin J Glaser4, Meng Yin4, Sudhakar K Venkatesh4, Bing Wu5, Richard L Ehman4, and Jin Wang1

1Department of Radiology, The third affiliated hospital of Sun Yat-sen University, Guangzhou, China, 2South China Normal University, Guangzhou, China, 3Department of Pathology, The third affiliated hospital of Sun Yat-sen University, Guangzhou, China, 4Department of Radiology, Mayo Clinic, Rochester, MN, United States, 5MR Research China, GE Healthcare, Beijing, China

2D MR elastography (MRE) has been shown to be the most accurate noninvasive technique for the detection and staging of liver fibrosis. Tissue stiffness quantification based on 3D MRE is theoretically more accurate while having comparable diagnostic accuracy for staging fibrosis. Our results showed that the diagnostic performance of 3D MRE is not inferior to 2D MRE in assessing liver fibrosis by using a noninferiority test of the area under the ROC curve based on the restricted maximum likelihood (REML) method. Moreover, 3D MRE had better image quality and has the potential to replace 2D MRE in clinical applications.

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