A Promising Procedure for the Staging of Liver Fibrosis Using Hepatocyte Fraction
Weibo Chen1, Tian Qiu2, Eunju Kim3, and YuXin Shi*2
1Philips Healthcare, Shanghai, China, 2Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, China, 3Philips Healthcare, Seoul, Korea, Republic of
Liver biopsy is an invasive and painful procedure for staging liver fibrosis. This study aimed to evaluate a new procedure by injecting a hepatobiliary-specific contrast agent Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) and using a pharmacokinetic model to stage the liver fibrosis noninvasively. The hepatocyte fraction extracted from this new model decreased as the liver fibrosis stage increased, indicating that it might be a promising biomarker for the noninvasive staging of liver fibrosis.
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