In this study, we assessed the value of various diffusion parameters obtained from monoexponential, biexponential, and stretched-exponential DWI models in predicting the hepatic fibrosis (HF) stage and inflammatory activity grade in patients with chronic hepatitis B (CHB). We found that true diffusion coefficient (Dt) and distributed diffusion coefficient (DDC) are promising indicators and outperform the standard apparent diffusion coefficient (ADCst) for HF staging and inflammatory activity grading. We believe that biexponential and stretched-exponential model could be more helpful compared with monoexponential model in monitoring the progression of HF and inflammatory activity, guiding therapy, and assessing the effect of the treatment.
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