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Abstract #1814

A radiomics approach to assess tumor-stromal ratio and predict treatment response to neoadjuvant chemoradiotherapy in rectal cancer: a preliminary study

Tingdan Hu1, Tong Tong1, Dan Huang2, and Jun Yang2

1Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China, 2Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China

This study concentrated on the correlation between radiomics parameters and the tumor-stromal ratio. We identified several radiomics parameters that may reflect the content of tumor-stroma. After constructed a radiomics signature based on the tumor-stromal ratio and furtherly applied the signature into the LARC patients with neoadjuvant chemoradiotherapy, we found that the TSR-conducted radiomics signature was significantly correlated with pCR and non-pCR. The radiomics signature may serve as a non-invasive imaging biomarker for pretreatment prediction of treatment response.

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