Quantitative intravoxel incoherent motion (IVIM) parameters derived from whole-tumor volume for predicting and assessing pathological complete response to neoadjuvant chemotherapy in locally advanced rectal cancer
Qiaoyu Xu1,2, Yanyan Xu1, Queenie Chan3, and Hongliang Sun1
1Radiology, China-Japan Friendship Hospital, Beijing, China, 2Radiology, Beijing Chao-yang Hospital, Beijing, China, 3Research center, Philips Healthcare, HongKong, China
Neoadjuvant chemotherapy has been widely applied in treating locally advanced rectal cancer (LARC) for effectively decreasing the local recurrence after total mesorectal excision(TME)1. Some of patients may achieve a pathological complete response (pCR). The pCR rate of LARC has been reported to be 10%–30%2-3. The imaging technique of intravoxel incoherent motion(IVIM) model, which could estimate tissue perfusion and diffusion components individually using multi-b-values was introduced to evaluate tumor treatment response4. In this study, we found that IVIM-dreived D values is a promising tool in predicting pCR status before therapy.
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