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Abstract #1833

MRI-Derived Patient Specific Molds for Cancer Lesion Analysis in the Prostate

David R Rutkowski1,2, Shane A Wells2, Brian Johnson3, Wei Huang4, David F Jarrard5, Joshua M Lang6, Steve Cho2, and Alejandro Roldán-Alzate 1,2

1Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 4Pathology, University of Wisconsin-Madison, Madison, WI, United States, 5Urology, University of Wisconsin-Madison, Madison, WI, United States, 6Medicine, University of Wisconsin-Madison, Madison, WI, United States

Magnetic Resonance Imaging (MRI), and emerging Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography (PET)/MRI, can be used to detect and locate prostate cancer. The accuracy of this method can be validated by comparing post-prostatectomy histopathology information to MRI and PET image data with the help of a custom prostate-sectioning device. This study is aimed at addressing sectioning device limitations proposed by previous studies and at developing a three-dimensional (3D) comparison method for MRI data and post-prostatectomy prostate geometries.

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