On breast DWI, the relative signal intensity of a lesion can be increased by exploiting the differences in signal decay between tumor and normal tissue at higher b values. Computing high b-value images rather than acquiring them directly can increase lesion conspicuity and decrease scan times, improving the potential utility of breast DWI for non-contrast screening. In women with invasive breast cancer, we investigated the differences in lesion conspicuity across b-values and between acquired and computed diffusion weighted images. Our findings showed maximal lesion conspicuity at higher b-values (1200-1500s/mm2), with acquired images generally providing higher conspicuity than computed images.
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