We aimed to explore the possible correlation between aortic flow and myocardial motion in Marfan syndrome (MFS) patients. MFS group presented lower mean velocity and higher retrograde flow in the ascending aorta (AAo). MFS group also exhibited lower basal systolic Vz and diastolic Vr, higher diastolic Vz, and prolonged diastolic TTPz. The mean velocity showed positive correlation with basal systolic Vz, diastolic Vz, and diastolic Vr. The retrograde flow was correlated with basal diastolic TTPz. In conclusion, the correlation between aortic flow and myocardial motion in MFS patients might provide helpful information in long-term surveillance in MFS patients.