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Abstract #1991

Non-invasive estimations of turbulence driven relative pressure drops – applying the concept of virtual fields on 4D flow MRI

David Marlevi1,2, Hojin Ha3,4, Joao Filipe Fernandes5, Tino Ebbers4, Pablo Lamata5, and David Nordsletten5,6

1Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Stockholm, Sweden, 2Clinical Sciences, Karolinska Institutet, Stockholm, Sweden, 3Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon, Korea, Republic of, 4Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 5Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 6Departments Biomedical Engineering and Cardiac Surgery, University of Michigan, Ann Arbor, MI, United States

4D flow MRI with six-directional flow encoding has enabled the assessment of turbulent flows, including mapping of incoherent flow variance. Using such, non-invasive estimation of turbulence-driven pressure drops can be computed. Here, we present an extension of the virtual-Work-Energy-Relative-Pressure method8 for the assessment of turbulence-driven pressure drops. Using the concept of virtual fields, the method accurately assesses pressure drops over a range of stenotic valve phantoms, being validated against catheter-based measurements. With virtual probing enabling the assessment of pressure drops through complex, narrow vasculatures, the incorporation of turbulence enhances the utility of the method, enabling for refined clinical hemodynamic analysis.

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