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Abstract #2010

Assessing myocardial infarct size by novel TRAFFn relaxation time method in lymphatic insufficient mice

Elias Yla-Herttuala1, Taina Vuorio1, Svetlana Laidinen1, Seppo Yla-Herttuala1,2, and Timo Liimatainen3,4

1A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 2Heart Center, Kuopio University Hospital, Kuopio, Finland, 3Research unit of medical imaging, physics and technology, University of Oulu, Oulu, Finland, 4Department of diagnostic radiology, Oulu University Hospital, Oulu, Finland

We applied novel RAFFn relaxation times (TRAFF2 and TRAFF4), T and T2 to study effects of cardiac lymphatic system in myocardial infarct (MI). Infarct size based on the TRAFF4 relaxation time maps was significantly larger in earlier time points post MI in wild-type compared to lymphatic insufficient mice groups. No differences were found in relaxation times between groups. Area-of-overestimation (AOE) values remained stable in lymphatic insufficient group while in wild-type group a decreasing trend of AOE was observed. We conclude that effects of lymphatics after MI can be detected based on infarct size difference measured with different relaxation times.

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