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Abstract #2026

The structural basis for haemodynamically compromising VT assessed using high-resolution late gadolinium enhanced cardiovascular magnetic resonance imaging under contrast steady state

John Whitaker1, Steven Kim2, Adam Connolly3, Radhouene Neji4, Rashed Karim3, Steven Williams3, Louisa O'Neill3, Rahul Mukherjee3, Henry Chubb3, Srijoy Mahapatra2, Luigi Camporota5, Matthew Wright3, John Silberbauer3, S├ębastien Roujol3, Martin Bishop3, Mark O'Neill3, and Reza Razavi3

1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Abbott, Minneapolis, MN, United States, 3King's College London, London, United Kingdom, 4Siemen's healthcare, London, United Kingdom, 5Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom

Using a translational porcine model, the structural basis for post myocardial infarction ventricular tachycardia was assessed using in-vivo cardiac magnetic resonance imaging. High-resolution LGE imaging was acquired under contrast steady state in order to allow detailed tissue characterisation. Arrhythmia was induced and assessed under haemodynamic support to allow the unambiguous identification of arrhythmogenic tissue involved in these scar mediated VT circuits. The electrophysiological and imaging data was then registered to establish the structural features of tissue involved in these rhythms. It was identified that tissue participating in the diastolic phase of post-MI VT was thinner, had non-transmual scar or intermediate signal intensity and had higher gradients in tissue thickness.

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