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Abstract #2030

Novel phase-sensitive late gadolinium enhancement MRI for assessment of myocardial infarction in large animals

Anna V Naumova1, Niranjan Balu1, Hiroshi Tsuchida2,3, Lauren E Neidig2,3,4, RS Thies2,3, Charles E Murry2,3, and Chun Yuan1

1Radiology, University of Washington, Seattle, WA, United States, 2Pathology, University of Washington, Seattle, WA, United States, 3Institute for Stem Cells and Regenerative Medicine, University of Washington, Seattle, WA, United States, 4Comparative Medicine, University of Washiington, Seattle, WA, United States

Novel phase sensitive reconstruction method of the gadolinium delayed hyperenhancement, 3D-TRIPS, was used for the first time in the infarct visualization and quantitation in the hearts of non-human primates and Yucatan mini-pigs. Advantages of using 3D-TRIPS reconstruction vs. standard 2D-PSIR method for MR imaging of infarct include scan time shortening due to elimination the background phase-reference scan and improvement of the contrast ratio between normal and infarcted myocardium as well as between scar and blood. The novel cardiac MRI 3D-TRIPS method provides robust infarct size measurements while preserving scan time.

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