The extent of collateralization/branching
(CB) of lower limb vessels in peripheral artery disease (PAD) can inform risk
of ischemia and response to revascularization. However quantitative imaging
metrics of CB have not been assessed in the setting of severe PAD. We developed
automated quantitative measurements of lower limb vascular morphology (pCafe)
and compared CB in patients undergoing revascularization for PAD. Assessment of
pCafe metrics in severe PAD suggests CB is increased with occlusion compared to
stenosis indicating compensatory CB development.