Cardiac amyloidosis (CA) is a clinical disorder that could result in early death. MRI is a valuable modality for diagnosis of CA, where late-gadolinium enhancement is typically used for assessing adverse outcomes. However, in the era of unknown long-term effects of the gadolinium, there is a need to investigate alternative imaging biomarkers associated with CA, which is the primary aim of this study. The secondary aim is to evaluate the association between MRI variables and mortality in CA. The results demonstrated that depressed left-atrial global longitudinal strain is significantly associated with biopsy-proven CA, independent of other MRI and clinical measures.