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Abstract #2220

Successfully Overcoming the Challenge: Cardiac Cine of Zebrafish in MRI.

Astrid Wietelmann1, Clemens Müller2, Arno Nauerth3, Didier Y.R. Stainier4, and Anabela Bensimon-Brito4

1MRI & µ-CT Service Group, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany, 2Kerckhoff-Klinik, Kerckhoff-Klinik, Bad Nauheim, Germany, 3Bruker BioSpin MRI GmbH, Ettlingen, Germany, 4Department III Developmental Genetics, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany

Zebrafish has been a widely used model to study cardiovascular development and diseases. Among the multiple advantages, zebrafish has the remarkable ability to regenerate lost or damaged organs including the heart. In vivo visualization of the cardiovascular system is particularly easy during early stages of development due to zebrafish transparency, which is lost in the adult stages. Therefore, it is of great interest to refine and adapt non-invasive imaging methods that allow a functional assessment of the zebrafish adult heart. The application of high-field functional MRI of the beating zebrafish heart will be presented and discussed.

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