This study evaluated
the performance of 9 unique methods of deriving GABA and GABA+ from J-edited-single-voxel-MRS
using a set of high-quality spectra obtained from the anterior middle cingulate
cortex in 34 pediatric human subjects. The results indicate that spectral
integration produces the most consistent between-subject measure of GABA+ and
that non-linear least-squares fitting that includes macromolecule confound
spectral models together with GABA spectral models best produces the expected
positive correlation between voxel gray matter content and GABA.