Proton 1D MR spectroscopy has been used to quantify alterations in cerebral metabolite concentrations to investigate neurological diseases. However, the J-coupling found in key metabolites produce multiplets which result in highly overlapped signals, complicating signal quantification. 2D J-resolved spectroscopy (JPRESS) allows distribution of coupled signals into a second perpendicular dimension, reducing signal overlap. Unfortunately, the translation of 2D-JPRESS into a commonly used clinical tool has not been achieved due to limited post-processing strategies and long scan times. Here, a simple processing strategy to significantly enhance signal sensitivity and a technique to accelerate JPRESS by 30% are presented.
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