Abstract #2250

Rapid High-Resolution Metabolic Imaging of Stroke Using SPICE

Tianxiao Zhang¹, Tianyao Wang², Ziyu Meng^1,3, Ke Xue¹, Yudu Li^3,4, Rong Guo^3,4, Yibo Zhao^3,4, Jun Liu², Zheng Jin⁵, Xin Yu⁶, Zhi-Pei Liang^3,4, and Yao Li¹

¹Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Radiology department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Shanghai minhang hospital of Integrated traditional Chinese and Western Medicine Hospital, Shanghai, China, ⁶Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Disrupted metabolic activity is one of the most prominent pathophysiologic consequences of stroke. ¹H-MRSI has been recognized as a powerful tool for metabolic imaging, but its clinical applications have been limited due to long scan time and poor spatial resolution. In this study, we investigate the feasibility of rapid high-resolution metabolic imaging of stroke using SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation). We have successfully acquired metabolic maps from the whole brain at a nominal spatial resolution of 2.0×2.4×2.0 mm³ in a 5-min scan. Our experimental results clearly show metabolic alterations due to stroke.

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