Disrupted metabolic activity is one of the most prominent pathophysiologic consequences of stroke. 1H-MRSI has been recognized as a powerful tool for metabolic imaging, but its clinical applications have been limited due to long scan time and poor spatial resolution. In this study, we investigate the feasibility of rapid high-resolution metabolic imaging of stroke using SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation). We have successfully acquired metabolic maps from the whole brain at a nominal spatial resolution of 2.0×2.4×2.0 mm3 in a 5-min scan. Our experimental results clearly show metabolic alterations due to stroke.