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Abstract #2254

Functional Magnetic Resonance Spectroscopy of response inhibition

Anouk Schrantee1,2, Jannie P Wijnen3, Petra JW Pouwels2,4, Niels de Joode4, Wietske van der Zwaag5, Liesbeth Reneman1,2, Odile A van den Heuvel2,4, and Chris Vriend2,4

1Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Amsterdam Neuroscience, Amsterdam, Netherlands, 3University Medical Center Utrecht, Utrecht, Netherlands, 4Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, Netherlands, 5Spinoza Centre for Neuroimaging, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, Netherlands

Ten volunteers performed a Go/NoGo task during MRS acquisition at 7T to assess if event-related fMRS could detect dynamic glutamate changes during response inhibition. Metabolite spectra were acquired using a semiLASER sequence (to assess task-induced fluctuations in glutamate and lactate) and were interleaved with water-unsuppressed spectra (to assess the BOLD response-induced water linewidth changes). The voxel was placed in the dorsomedial prefrontal cortex. Although an fMRI pilot confirmed the voxel location, no significant differences in metabolite concentrations or water amplitude between NoGo and Go trials was detected.

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