Alzheimer’s disease (AD) is a neurodegenerative disorder commonly associated with neuronal metabolic deficits. In this study, we employ an indirect 1H-[13C] MRS approach to investigate changes in glucose metabolism between wild type and transgenic Alzheimer rats. This method can be used to follow the labeling of downstream metabolites after [1-6,13C2] glucose infusion and allows for quantitative measurements of the rate of 13C-label transfer from glucose into glutamate and glutamine in the brain. Preliminary comparison of 13C fractional enrichment time courses suggest that transgenic rats exhibit slower 13C metabolite labeling, indicative of a lowered glucose metabolic rate in AD pathology.
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