Abstract #2269

Modulation of brain oxidative and glycolytic metabolisms using a finger tapping task: an ASL-fMRI and fMRS study

Yohan Boillat¹, Lijing Xin², Olivier Reynaud^2,3, Wietske van der Zwaag^2,4, and Rolf Gruetter^1,2

¹Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³Fondation Campus Biotech Geneva, Geneva, Switzerland, ⁴Spinoza Centre for Neuroimaging, Amsterdam, Netherlands

Using [Lac] and [Glu] as markers of glycolytic and oxidative metabolisms, respectively, we investigated the involvement of each of these pathways during a finger tapping task at different frequencies. We measured BOLD and CBF data and metabolite concentrations at 7T. BOLD and CBF signals increased for increasing finger tapping frequencies as well as [Lac]. The [Glu] changes were smaller and, with the current number of participants, did not follow the same trend.

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