Meeting Banner
Abstract #2275

Potential Celiac disease (CeD) patients may serve as pre-clinical model to understand pathogenesis of Celiac Disease: A NMR metabonomics approach

Deepti Upadhyay1, Naranamangalam R Jagannathan1, Govind K Makharia 2, Siddharth Datta Gupta3, Prasenjit Das3, and Uma Sharma1

1Department of NMR & MRI Facility, All India Institute of Medical Sciences (AIIMS), New Delhi, India, 2Department of Gastroenterology and human Nutrition, All India Institute of Medical Sciences, New Delhi, India, 3Department of Pathology, All India Institute of medical sciences, New Delhi, India

Potential celiac disease (CeD) patients have positive CeD associated antibodies (anti-tissue tansglutaminase antibodies) and HLA-DQ2 and/or HLA-DQ8 genotype but no intestinal inflammation. NMR based metabonomic study of blood plasma of potential CeD patients demonstrated a distinct metabolic fingerprint characterized by raised histidine and proline in comparison to healthy controls. The changes in histidine suggested compromised cytoprotective mechanism while elevated arginine level indicated altered functioning of intestinal cells in potential CeD. These altered metabolic activities could be the initial event that precede the pathogenesis of CeD and may contribute to intestinal inflammation which results in villous atrophy.

This abstract and the presentation materials are available to members only; a login is required.

Join Here