Abstract #2285

High-grade and low-grade prostate cancer discrimination via blood plasma NMR based metabolomics

Pradeep Kumar¹, Rajeev Kumar², Virendra Kumar¹, S. Senthil Kumaran¹, Sanjay Sharma³, Sanjay Thulkar³, S. Datta Gupta⁴, and Naranamangalam R. Jagannathan¹

¹Department of NMR & MRI Facility, India Institute of Medical Sciences, New Delhi, India, NEW DELHI, India, ²Department of Urology, India Institute of Medical Sciences, New Delhi, India, New Delhi, India, ³Department of Radio-diagnosis, All India Institute of Medical Sciences, New Delhi, India, New Delhi, India, ⁴Department of Pathology, All India Institute of Medical Sciences, New Delhi, India, New Delhi, India

This study investigates the metabolic profile of blood plasma for distinguishing prostate cancer (PCa) patients with high Gleason score (GS≥7) and low Gleason score (GS<7) using ¹H-NMR metabolomics. A significantly higher concentration of lactate, pyruvate, choline, dimethylamine, acetate and alanine were observed in the blood plasma of PCa patients with high Gleason score as compared to patients with low Gleason score. Our results suggested that the metabolic pathway alterations seen in amino acids, choline, glucose and ketone body may be related to changes in PCa progression.

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