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Abstract #2304

In vivo evaluation of pentose phosphate pathway activity in orthotopic glioma using hyperpolarized δ-[1-13C]gluconolactone

Georgios Batsios1, Pavithra Viswanath1, Peng Cao1, Celine Taglang1, Elavarasan Subramani1, Robert Flavell1, Peder Larson1, and Sabrina Ronen1

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States

Flux via the pentose phosphate pathway (PPP) is typically upregulated in tumor cells. Imaging this upregulation could therefore help in monitoring tumor development and response to treatment. A previous study presented the use of hyperpolarized δ-[1-13C]gluconolactone to detect flux through PPP by monitoring its conversion to 6-phospho-[1-13C]gluconate in isolated perfused livers. Here, we demonstrate that HP δ-[1-13C]gluconolactone can also be used to monitor PPP activity in healthy brain and in gliomas, and that the ratio of HP 6-phospho-[1-13C]gluconate to 6-phospho-δ-[1-13C]gluconolactone is significantly higher in tumor regions compared to healthy brain.

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