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Abstract #2351

IDH Genotypes Differentiation in Glioblastomas Using DWI and DSC-PWI in the Enhancing and Peri-Enhancing Region

Hua Zhang1, Dairong Cao1, Zhen Xing1, Dejun She1, Yu Lin1, Zhongshuai Zhang2, and Mengxiao Liu2

1Department of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China, 2Scientific Marketing, SIEMENS Healthcare, Diagnostic Imaging, Shanghai, China

The purpose of this study is to evaluate the contribution of DWI and DSC-PWI in the peri-enhancing region for discriminating glioblastomas IDH genotypes. Further, the diagnostic value of this two MR techniques were compared with those in the enhancing portion. Features of conventional MRI, rADCmin-t, rADCmin-p, rCBVmax-t and rCBVmax-p were compared between IDH-m and IDH-w glioblastomas. IDH-mutated glioblastomas tended to present in frontal lobes and younger patients. Both rCBVmax-t and rCBVmax-p show significant difference between two subgroups, while rADCmin-t and rADCmin-p do not. The results showed that the accuracy of rCBVmax-p is higher than that of rCBVmax-t in the diagnosis of IDH-m glioblastomas. rCBVmax-p may have a better diagnostic value than rCBVmax-t in predicting IDH glioblastomas genotypes.

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