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Abstract #2358

Non-gaussian IVIM-DWI for HPV-related oropharyngeal cancer patients who received marked dose de-escalation in chemo-radiotherapy: Intra-treatment imaging response evaluation

Ramesh Paudyal1, Nadeem Riaz2, Vaios Hatzoglou3, Nancy Lee2, and Amita Shukla-Dave1,3

1Medical Physcis, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

This study aims to evaluate treatment response in human papillomavirus-related (HPV+) oropharyngeal squamous cell carcinoma using pre- treatment (TX), intra- TX week 1, 2, 3, and post-TX week 4 quantitative imaging metrics derived from non-Gaussian IVIM DWI. ADC and D showed a significant increase between pre- and post-TX week 4 in complete response (CR) group, who were treated with dose de-escalation to 30Gy chemo-radiation therapy.

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