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Abstract #2479

Non-Water suppressed High-Resolution 1H-MRSI of the Brain Using Short-TE SPICE with semi-LASER Concentric Ring Trajectory Acquisition

Uzay Emir1,2, Pingyu Xia1, Ulrike Dydak1,3, Xiaopeng Zhou1, Albert Thomas4, Mark Chiew5, Rong Guo6,7, Yudu Li6,7, Yibo Zhao6,7, and Zhi-Pei Liang6,7

1School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 3Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 4Department of Radiology, University of California Los Angeles, Los Angeles, CA, United States, 56Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 6Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Illinois 2Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Illinois Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, IL, United States, 7Department of Electrical and Computer Engineering, University of Illinois, Urbana-Champaign, IL, United States

Magnetic resonance spectroscopic imaging (MRSI) is an appealing technique in both research and clinical settings. However, the utility of MRSI has been hampered by long acquisition times and artifacts caused by lipid contamination and poor water suppression. Recent advances in MRSI acquisition and preprocessing, like concentric rings (CRT) trajectories and SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation) (REF3), have overcome some of these issues. This work reports our success in integrating SPICE with CRT acquisitions to address the challenges of sensitivity, spectral quality, speed, and spatial resolution.

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