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Abstract #2488

High-Resolution T1 maps of Brain Metabolites

Antoine Klauser1, Frédéric Grouiller2, Sebastien Courvoisier1, and Francois Lazeyras1

1CIBM, Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland, 2Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland

High-resolution T1 maps are measured over the whole human brain with proton FID-MRSI with incremental flip-angles. MRSI datasets with multiple flip-angles are reconstructed simultaneously through a low-rank-total generalized variation model and T1 values are determined by fit of the steady state magnetization with B1 inhomogeneity correction. Twofold compressed-sensing acceleration enables acquisition of a single flip-angle in 5 min and resulting in acquisition of 3 flip-angles in 15 min. Precise determination of T1 would enables an accurate correction of signal loss and might provide important information on brain micro-structure.

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