Meeting Banner
Abstract #2505

NOE enhancement for 31P-MRS of skeletal and cardiac muscle at 7T

Chang-Hoon Choi1,2, Ladislav Valkovic2,3, William T. Clarke4, Albrecht I. Schmid2,5, N. Jon Shah1,6,7,8, and Christopher T. Rodgers2,9

1Institute of Neuroscience and Medicine-4, Forschungszentrum Juelich, Juelich, Germany, 2Oxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, 3Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislave, Slovakia, 4Wellcome Centre for Integrative Neuroimaging, FMRIB, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, 5High-Field MR Centre, Centre for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 6Institute of Neuroscience and Medicine-11, JARA, Forschungszentrum Juelich, Juelich, Germany, 7JARA-BRAIN-Translational Medicine, Aachen, Germany, 8Department of Neurology, RWTH Aachen University, Aachen, Germany, 9The Wolfson Brain Imaging Centre, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom

Phosphorus MR spectroscopy (31P-MRS) is a proven method for probing tissue energetics and membrane metabolism. Nuclear Overhauser effect (NOE) enhancement can considerably improve the quality of 31P spectra. This has been demonstrated in the brain and prostate at 7T, but NOE has not yet been applied elsewhere in the human body at 7T. In this study, we evaluated NOE enhancement for 31P-MRS in human skeletal muscle and in the heart in vivo at 7T. We observe significant enhancements (e.g. for PCr/γ-ATP: 25%/16% in muscle, 31%/11% in heart), within regulatory SAR limits and without increasing the scan duration.

This abstract and the presentation materials are available to members only; a login is required.

Join Here