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Abstract #2508

An Optimized PRESS Sequence for the Detection of 13C4-Glutamate at 9.4 T

Brennen J. Dobberthien1, Anthony G. Tessier1,2, and Atiyah Yahya1,2

1Department of Oncology, University of Alberta, Edmonton, AB, Canada, 2Department of Medical Physics, Cross Cancer Institute, Edmonton, AB, Canada

Glutamate (Glu) incorporates 13C label on its C4 carbon (13C4-Glu) following a 13C-labelled glucose (Glc) infusion, resulting in a ≈2.51ppm proton “satellite” peak that provides an indirect measure of 13C4-Glu. Quantification of the satellite peak is complicated at short echo time (TE) due to overlap with the ≈2.49ppm N-acetylaspartate (NAA) peak. A PRESS, point resolved spectroscopy, (TE1, TE2) combination of (20ms, 106ms) was found to be suitable for resolving the ≈2.51ppm 13C4-Glu proton peak from that of NAA at 9.4T by exploiting differences in J-coupling evolution. The efficacy of the technique is verified on rat brain during a [U-13C6]-Glc infusion.

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