Abstract #2511

Enhanced sodium quantification accuracy in a 3T clinical 23Na MR stroke study

Nadia Karina Paschke¹, Roberta Egoriti^1,2, Manuel Winkler^1,3, Eva Neumaier-Probst⁴, Sherif Mohamed⁴, Melina Samartzi⁵, Marc Fatar⁵, and Lothar Rudi Schad¹

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Biomedical Engineering, Politecnico di Milano, Milan, Italy, ³Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ⁴Department of Neuroradiology, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany, ⁵Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Tissue sodium quantification from sodium magnetic resonance acquisitions is a promising biomarker in ischemic stroke diagnostics and can be incorporated in clinical magnetic resonance protocols. Since no gold standard of protocol design and post-processing exists yet, we investigated three research questions for enhanced sodium quantification in 20 stroke patients: Are transmission field corrections necessary? Should the relaxation behavior be included in the quantification? Should manual evaluations of region of interests be replaced by automatic whole brain segmentation analyses? Based on this study, we propose to include user-independent segmentation and relaxation correction in 23Na whole brain analysis, while omitting transmission corrections.

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