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Abstract #2548

Effects of Transcranial Direct Current Stimulation on Metabolite Concentrations in Children

Chidera Nwaroh1,2,3,4, Lauran Cole2,3,5,6, Adrianna Giuffre2,3,5,6, Helen Carlson2,6,7, Frank P MacMaster2,3,4,7,8,9,10, Adam Kirton2,3,6,7, and Ashley D Harris1,2,3,4

1Department of Radiology, University of Calgary, Calgary, AB, Canada, 2Alberta Children's Hospital Research Institute (ACHRI), Calgary, AB, Canada, 3Hotchkiss Brain Institute, Calgary, AB, Canada, 4Child and Adolescent Imaging Research (CAIR) Program, Calgary, AB, Canada, 5Department of Neuroscience, University of Calgary, Calgary, AB, Canada, 6Calgary Pediatric Stroke Program, Alberta Children's Hospital, Calgary, AB, Canada, 7Department of Pediatrics, University of Calgary, Calgary, AB, Canada, 8Department of Psychiatry, University of Calgary, Calgary, AB, Canada, 9The Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada, 10Strategic Clinical Network for Addictions and Mental Health, Calgary, AB, Canada

Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation that safely modulates brain activity. Several studies have shown that tDCS of the motor cortex facilitates motor learning and plasticity but there is little information on the underlying mechanisms. This analysis of metabolite changes in response to 1mA tDCS using typical PRESS and MEGA-PRESS is important in developing a complete understanding of the effects of stimulation. In this pediatric study, we did not detect the same GABA and glutamate changes in response to tDCS that have been seen in the adult literature.

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