There are still debates on the alterations of subcortical metabolism in Parkinson’s disease. We performed 3D pseudo-continuous pulse ASL on PD and control groups. The absolute cerebral blood flow (CBF) values and relative CBF (rCBF) in subcortical regions were automatically extracted and calculated. We found widespread decreased absolute CBF in PD patients. However, the subcortical rCBF increased significantly. We conclude that widespread blood hypoperfusion in PD brain is absolute, and hyperperfusion in the subcortical brain regions is only relative to the whole brain level of patients themselves.