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Abstract #2579

Longitudinal Changes in Cerebral Blood Flow Calculated by Arterial Spin Labeling MRI in Parkinson’s Disease

Dilek Betul Arslan1, Sevim Cengiz1, Kardelen Eryurek2, Ozan Genc1, Ani Kicik2, Emel Erdogdu2,3, Zeynep Tufekcioglu4, Basar Bilgic4, Hasmet Hanagasi4, Aziz Mufit Ulug1, Ibrahim Hakan Gurvit4, Tamer Demiralp2,5, and Esin Ozturk-Isik1

1Biomedical Engineering Institute, Bogazici University, Istanbul, Turkey, 2Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, 3Institute of Psychology and Cognition Research, University of Bremen, Bremen, Germany, 4Department of Neurology, Istanbul University, Istanbul, Turkey, 5Department of Physiology, Istanbul University, Istanbul, Turkey

The aim of this study is to monitor perfusion changes over one and a half years in Parkinson’s disease with mild cognitive impairment (PD-MCI). Cerebral blood flow (CBF) maps were created for baseline and follow-up scans by fitting a kinetic curve model for each pixel of arterial spin labeling MR images. The CBF maps were registered to MNI152 brain atlas, and perfusion changes were assessed at 119 distinct brain regions. The CBF of PD-MCI patients decreased at occipital fusiform gyrus, right occipital fusiform gyrus, anterior part of left supramarginal gyrus, and anterior part of right middle temporal gyrus over time.

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