Abstract #2597

Towards identification of neuroanatomical correlates of neuropsychological scores in Parkinson’s disease patients, with and without, memory impairment

Virendra R Mishra¹, Karthik R Sreenivasan¹, Ece Bayram², Sarah J Banks³, Jason Longhurst², Zhengshi Yang¹, Xiaowei Zhuang¹, Dietmar Cordes¹, Aaron Ritter², Jessica Caldwell², and Brent Bluett⁴

¹Imaging Research, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, ²Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, ³University of California, San Diego, San Diego, CA, United States, ⁴Department of Neurology and Neurosciences Stanford Movement Disorders Center (SMDC), Stanford University, Stanford, CA, United States

With a well-characterized dataset of Parkinson’s disease (PD) participants, with and without memory impairment, this study shows that there is a distinct structural network organization between PD with mild cognitive impairment (PD-MCI) and without MCI(PD-nMCI). This study further shows that while there are no discernible differences in scalar diffusion-MRI derived measures, fractional anisotropy in PD-nMCI is negatively associated with trail making test-A. Our study demonstrates the feasibility towards identifying neuroanatomical correlates of neuropsychological scores that will not only aid in our understanding of the underlying neural correlates of cognitive impairment in PD, as well as differentiating PD-MCI and PD-nMCI in an objective and reproducible manner.

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