Abstract #2618

Gradient profiles of myelin and microstructure metrics across the developing brain

Erika P Raven¹, Maxime Chamberland¹, Sila Genc^1,2,3, Kate Duffy¹, Chantal Tax¹, Greg Parker¹, Maxime Descoteaux⁴, and Derek K Jones¹

¹Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, ²Developmental Imaging, Murdoch Children’s Research Institute, Parkville, Australia, ³Department of Paediatrics, University of Melbourne, Parkville, Australia, ⁴University of Sherbrooke, Sherbrooke, QC, Canada

Myelinogenesis follows a protracted sequence, with distinct pathways being myelinated at various times throughout development. To test this with MRI, we used magnetization transfer and diffusion metrics with tractography to investigate along-tract profiles of myelin and microstructure metrics in children and adolescents. Profiles demonstrated sensitivity to along-tract metrics, with midline regions having increased myelin and restricted diffusion indices indicative of maturation.

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