Abstract #2634

The visualization of the morphology change within depigmented substantia nigra using high field postmortem MRI

Hansol Lee¹, Sun-Yong Baek², Eun-Joo Kim³, Gi Yeong Huh⁴, Jae-Hyeok Lee⁵, and HyungJoon Cho¹

¹Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, ²Department of Anatomy, Pusan National University School of Medicine, Yangsan, Korea, Republic of, ³Department of Neurology, Pusan National University Hospital, Busan, Korea, Republic of, ⁴Department of Forensic Medicine, Pusan National University School of Medicine, Yangsan, Korea, Republic of, ⁵Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Korea, Republic of

The purpose of this study was to determine the alteration of the morphology in the substantia nigra using MRI with histopathological validation for the patients of atypical Parkinsonism. MR experiments for formalin fixed autopsied brains were operated using a 7T imaging system. Specific visualization of ferric iron and neuromelanin from MR relaxometry was used to identify the neuromelanin distribution within the normal brain and the brain of Perry syndrome. The loss of neuromelanin pigment within the substantia nigra of Perry syndrome was consistently confirmed both from MR relaxometry and from the directly captured picture during the cryo-section.

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